Fraser I P, Koziel H, Ezekowitz R A
Laboratory of Developmental Immunology and Department of Pediatrics, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.
Semin Immunol. 1998 Oct;10(5):363-72. doi: 10.1006/smim.1998.0141.
The innate immune system evolved to protect the host in the early phases of an infectious challenge. The soluble mannose binding protein, and the cell surface mannose receptor are two key pattern recognition molecules of innate immunity. The ligand binding specificity of these molecules enables them to differentiate 'self' from 'non-self'. These pattern recognition capabilities are coupled to effector functions, which enable them to interact with other molecules of the immune system. In this way, these pattern recognition molecules are able to serve as a link between the innate and adaptive immune systems.
先天免疫系统进化而来，以便在感染挑战的早期阶段保护宿主。可溶性甘露糖结合蛋白和细胞表面甘露糖受体是先天免疫的两个关键模式识别分子。这些分子的配体结合特异性使它们能够区分“自身”和“非自身”。这些模式识别能力与效应功能相关联，使它们能够与免疫系统的其他分子相互作用。通过这种方式，这些模式识别分子能够充当先天免疫系统和适应性免疫系统之间的纽带。
