Craciun C, Ghircoiasiu M, Craciun V
Babes-Bolyai University, Dept. Biology, Cluj-Napoca, Romania.
Acta Morphol Hung. 1992;40(1-4):231-48.
Calcium pantothenate was administered to Wistar rats in a dose of 180 mg/day/rat for 42 days, in order to investigate its effect upon the ultrastructure of the epidermis locally irradiated with a dose of 600 rep and upon partly hepatectomized liver and locally irradiated epidermis, as compared to control. The resulting data have revealed that calcium pantothenate is metabolized without entailing ultrastructural changes. Both liver and epidermis appear to be protected by calcium pantothenate, which greatly diminishes or even cancels the display of irradiation-induced negative effects. The changes brought about by irradiation are throughly presented and the subcellular mechanisms providing the radioprotection of epidermis and liver are accurately defined.
为了研究泛酸钙对局部接受600伦琴剂量照射的表皮超微结构以及对部分肝切除的肝脏和局部照射的表皮的影响，并与对照组进行比较，以每天每只大鼠180毫克的剂量给Wistar大鼠施用泛酸钙，持续42天。所得数据表明，泛酸钙在代谢过程中不会引起超微结构变化。肝脏和表皮似乎都受到泛酸钙的保护，泛酸钙能大大减少甚至消除辐射诱导的负面影响。文中全面呈现了辐射引起的变化，并准确界定了为表皮和肝脏提供辐射防护的亚细胞机制。
