Lolova I, Davidoff M
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Mech Ageing Dev. 1992 Nov;66(2):195-211. doi: 10.1016/0047-6374(92)90136-2.
Parvalbumin (PV)- and calbindin (CaBP)-immunostaining in the hippocampal formation of 3-, 11- and 28-month-old Wistar rats was studied using monoclonal antibodies. A quantitative analysis of the densities, cross-sectional areas, length and number of processes of PV-immunoreactive neurons in the hippocampal dentata and CA1 areas of the three age groups was employed. Marked age-related changes in the morphological appearance and in the quantitative parameters characterizing the PV-immunoreactive neurons in both hippocampal regions were observed. The intensity of CaBP-immunostaining of the hippocampal principle cells and interneurons remained the same but the immunoreactive fibers were structurally altered in aging.
使用单克隆抗体研究了3个月、11个月和28个月大的Wistar大鼠海马结构中小白蛋白（PV）和钙结合蛋白（CaBP）的免疫染色情况。对三个年龄组大鼠海马齿状回和CA1区中PV免疫反应性神经元的密度、横截面积、突起长度和数量进行了定量分析。观察到两个海马区域中PV免疫反应性神经元的形态外观和定量参数存在明显的年龄相关变化。海马主细胞和中间神经元的CaBP免疫染色强度保持不变，但衰老过程中免疫反应性纤维的结构发生了改变。
