Steiner H, Huston J P
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.
Psychopharmacology (Berl). 1992;109(4):390-4. doi: 10.1007/BF02247713.
It has been shown that peripheral manipulation of sensory input by removal of vibrissae on one side of the rat's face induces turning behavior which is directed towards the contralateral vibrissae-intact side, under the influence of the dopamine receptor agonist apomorphine. In the present experiment, we examined whether rats under apomorphine turn towards the side with more sensory input, or simply away from the manipulated side. Thus, an experimental manipulation was designed to increase sensory input. Sensory stimulation was applied by attaching a clip into the fur on one side of the face. Rats injected with apomorphine in doses of 0.5-5.0 mg/kg (but not with 0.05 mg/kg or vehicle) exhibited turning behavior towards the side of the clip. This sensory stimulation was also found to influence spontaneous behavioral asymmetries. These results show that an imbalance in sensory input is sufficient to produce turning under apomorphine.
研究表明，在多巴胺受体激动剂阿扑吗啡的影响下，通过去除大鼠一侧面部的触须对感觉输入进行外周操纵，会诱发大鼠转向对侧触须完整一侧的转向行为。在本实验中，我们研究了接受阿扑吗啡的大鼠是转向感觉输入更多的一侧，还是仅仅远离被操纵的一侧。因此，设计了一种实验操作来增加感觉输入。通过在面部一侧的皮毛上夹一个夹子来施加感觉刺激。注射剂量为0.5 - 5.0 mg/kg（但不是0.05 mg/kg或赋形剂）阿扑吗啡的大鼠表现出转向夹子一侧的转向行为。还发现这种感觉刺激会影响自发行为不对称性。这些结果表明，感觉输入的不平衡足以在阿扑吗啡作用下产生转向行为。
