Milani H, Schwarting R K, Kumpf S, Steiner H, Huston J P
Institute of Physiological Psychology I, University of Düsseldorf, Federal Republic of Germany.
Behav Neurosci. 1990 Jun;104(3):470-6. doi: 10.1037//0735-7044.104.3.470.
Spontaneous and drug-induced turning behavior and thigmotactic scanning were tested either acutely (4-6 hr) or chronically (9 days) after unilateral removal of vibrissae in rats. Rats that were tested acutely scanned more with the intact vibrissae side. This asymmetry was reduced in rats that were tested chronically, indicating behavioral recovery. The indirect dopamine agonist amphetamine induced a reversed asymmetry after 9 days because the animals then scanned more with the side lacking the vibrissae. Postsynaptic doses of apomorphine administered to acutely tested rats induced more scanning with, and more turning toward, the intact vibrissae side. A negative correlation was found in the chronically tested rats between the asymmetry in spontaneous scanning and the asymmetry after apomorphine. Nonrecovered rats showed indications of a reversal after apomorphine. The results are discussed in relation to mechanisms of neural plasticity in the basal ganglia, such as receptor supersensitivity and changes in nigrostriatal afferents.
在大鼠单侧去除触须后，对其自发和药物诱导的转向行为以及趋触性扫描进行了急性（4 - 6小时）或慢性（9天）测试。急性测试的大鼠更多地用完好触须侧进行扫描。在慢性测试的大鼠中这种不对称性降低了，表明行为恢复。间接多巴胺激动剂苯丙胺在9天后诱导出相反的不对称性，因为此时动物更多地用缺乏触须的一侧进行扫描。给急性测试的大鼠施用突触后剂量的阿扑吗啡会诱导更多地用完好触须侧进行扫描，并更多地转向该侧。在慢性测试的大鼠中，自发扫描的不对称性与阿扑吗啡后的不对称性之间存在负相关。未恢复的大鼠在阿扑吗啡后显示出反转的迹象。结合基底神经节神经可塑性的机制，如受体超敏反应和黑质纹状体传入纤维的变化，对结果进行了讨论。
