Hansson L, Hedner T, Dahlöf B
Department of Medicine, University of Göteborg, Ostra Hospital, Sweden.
Blood Press. 1992 Aug;1(2):113-9. doi: 10.3109/08037059209077502.
A novel design for intervention studies is presented, the so called PROBE study (Prospective Randomized Open, Blinded End-point). This design is compared to the classical double-blind design. Among the advantages of the PROBE design are lower cost and greater similarity to standard clinical practice, which should make the results more easily applicable in routine medical care. Since end-points are evaluated by a blinded end-point committee it is obvious that there should be no difference between the two types of trials in this regard.
本文提出了一种干预研究的新设计，即所谓的PROBE研究（前瞻性随机开放、终点设盲）。将这种设计与经典的双盲设计进行了比较。PROBE设计的优点包括成本较低以及与标准临床实践更相似，这应使结果在常规医疗护理中更易于应用。由于终点由一个设盲的终点委员会进行评估，显然在这方面两种类型的试验应该没有差异。
