Greenwood R D, Nadas A S
Pediatrics. 1976 Dec;58(6):893-7.
There was 230 patients with heart disease among 369 infants and children with Down's syndrome. The majority exhibited defects of the endocardial cushion variety and approximately one quarte had complete atrioventricular canals (CAVC). Pulmonary artery hypertension was uniform in catheterized patients in this latter group and frequent in all left-to-right shunts. Medical and surgical mortality was high (33%) in these 230 children and especially in those with CAVC and tetralogy of Fallot. Only 4% (76 of 1,916) of infants with critical heart disease in New England had Down's syndrome and the most frequent lesion encountered was complete atrioventricular canal.
在369例患有唐氏综合征的婴幼儿中，有230例患有心脏病。大多数表现为心内膜垫缺损类型，约四分之一患有完全性房室通道（CAVC）。后一组接受导管检查的患者中肺动脉高压普遍存在，在所有左向右分流中也很常见。这230名儿童的内科和外科死亡率很高（33%），尤其是患有完全性房室通道和法洛四联症的儿童。在新英格兰，患有严重心脏病的婴儿中只有4%（1916例中的76例）患有唐氏综合征，最常见的病变是完全性房室通道。
