中性树脂对发酵生产红曲菌素的影响。

The effect of neutral resins on the fermentation production of rubradirin.

作者信息

Marshall V P, McWethy S J, Sirotti J M, Cialdella J I

机构信息

Research Laboratories, Upjohn Company, Kalamazoo, MI 49001.

出版信息

J Ind Microbiol. 1990 Jul;5(5):283-7. doi: 10.1007/BF01578202.

DOI:10.1007/BF01578202

PMID:1366609

Abstract

Rubradirin is an antibiotic of complex chemical structure which is active vs. methicillin resistant staphylococci. Its development has been limited due to inadequate production yields. The incorporation of neutral resins into fermentations of Streptomyces achromogenes v. rubradiris, UC 8051 resulted in the enhanced production of rubradirin. Resins HP-20, HP-21, XAD-2, XAD-7 and XAD-16 were employed in flask and tank fermentations. The incorporation of these resins promoted 2- to 4-fold enhancements of the rubradirin activity produced in flask fermentations, and the incorporation of XAD-16 and HP-21 into tank fermentations promoted production titer increases greater than 5 fold.

摘要

鲁布拉地霉素是一种化学结构复杂的抗生素，对耐甲氧西林葡萄球菌具有活性。由于产量不足，其开发受到限制。将中性树脂加入到产色链霉菌变种鲁布拉地霉菌（UC 8051）的发酵过程中，可提高鲁布拉地霉素的产量。在摇瓶和罐式发酵中使用了HP - 20、HP - 21、XAD - 2、XAD - 7和XAD - 16树脂。这些树脂的加入使摇瓶发酵中产生的鲁布拉地霉素活性提高了2至4倍，而在罐式发酵中加入XAD - 16和HP - 21使生产效价提高了5倍以上。