光果甘草细胞悬浮培养物对18β-甘草次酸的生物转化
Biotransformation of 18 beta-glycyrrhetinic acid by cell suspension cultures of Glycyrrhiza glabra.
作者信息
Hayashi H, Fukui H, Tabata M
机构信息
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
出版信息
Phytochemistry. 1990;29(7):2149-52. doi: 10.1016/0031-9422(90)83026-w.
Two biotransformation products formed from 18 beta-glycyrrhetinic acid by cell suspension cultures of Glycyrrhiza glabra were isolated and their structures determined by chemical and spectral data as 3-O-[alhpa-L-arabinopyranosyl-(1----2)-beta-D-Glucuronopy ranosyl]-24- hydroxy-18 beta-glycyrrhetinic acid and 30-O-beta-D-glycopyrano-syl-18 beta-glycyrrhetinic acid. The formation of glycyrrhizin, the main triterpene glucuronide of the licorice root, was not detected among the biotransformation products. This is the first report of the glucuronylation of an exogenous triterpene in plant cell cultures.
从光果甘草细胞悬浮培养物中由18β-甘草次酸形成的两种生物转化产物被分离出来，并通过化学和光谱数据确定其结构为3-O-[α-L-阿拉伯吡喃糖基-(1→2)-β-D-葡萄糖醛酸吡喃糖基]-24-羟基-18β-甘草次酸和30-O-β-D-吡喃葡萄糖基-18β-甘草次酸。在生物转化产物中未检测到甘草根主要三萜葡萄糖醛酸苷甘草酸的形成。这是植物细胞培养中外源三萜葡萄糖醛酸化的首次报道。
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