BJORNEBOE M, SCHWARTZ M
J Exp Med. 1959 Aug 1;110(2):259-70. doi: 10.1084/jem.110.2.259.
On hyperimmunization of rabbits with pneumococcal vaccine, increase in the content of gamma globulin and fall of albumin in the serum are produced. In such hyperimmunized rabbits, investigations of the plasma volume, albumin degradation, and the distribution of the albumin intra- and extravascularly were undertaken by Sterling's method employing rabbit albumin labelled with I(131). The investigations do not suggest any significant alteration in the albumin degradation nor in the distribution between the intra- and extravascular albumin. It was demonstrated that the plasma volume increases simultaneously with increase in the gamma globulin and fall in albumin. It is concluded that the fall in serum albumin observed is due to a regulative mechanism which attempts to maintain the colloid-osmotic pressure by increasing the plasma volume.
用肺炎球菌疫苗对家兔进行超免疫时，血清中γ球蛋白含量增加而白蛋白含量下降。在用131I标记的兔白蛋白，采用斯特林方法对这些超免疫家兔的血浆容量、白蛋白降解以及白蛋白在血管内和血管外的分布进行了研究。研究结果表明，白蛋白降解以及血管内和血管外白蛋白的分布均无明显改变。结果表明，血浆容量随着γ球蛋白的增加和白蛋白的下降而同时增加。得出的结论是，观察到的血清白蛋白下降是由于一种调节机制，该机制试图通过增加血浆容量来维持胶体渗透压。
