Nanji A A, Campbell D J, Pudek M R
JAMA. 1981 Aug 21;246(8):859-60.
Anion gaps were determined in 82 patients with hypoalbuminemia; 24 of these patients had a polyclonal increase in gamma-globulin levels (designated group 5). The 58 patients without the polyclonal increase in gamma-globulin levels were subdivided according to the origin of their serum albumin loss as follows: group 1, renal group 2, gastrointestinal; group 3, skin; and group 4, malignant neoplasms. All groups had a statistically significant reduction in their mean anion gaps when compared with normal control subjects. The greatest decrease was when hypoalbuminemia was accompanied by a polyclonal increase in gamma-globulin levels. Hypoalbuminemia with or without a polyclonal gammopathy is a cause of a low anion gap. No statistically significant correlation was found between the anion gaps and individual serum albumin concentrations.
对82例低白蛋白血症患者测定了阴离子间隙；其中24例患者γ球蛋白水平呈多克隆性升高（指定为第5组）。将58例γ球蛋白水平无多克隆性升高的患者根据血清白蛋白丢失的来源进行如下细分：第1组，肾脏；第2组，胃肠道；第3组，皮肤；第4组，恶性肿瘤。与正常对照受试者相比，所有组的平均阴离子间隙均有统计学意义的降低。当低白蛋白血症伴有γ球蛋白水平多克隆性升高时，降低幅度最大。伴有或不伴有多克隆性丙种球蛋白病的低白蛋白血症是阴离子间隙降低的一个原因。未发现阴离子间隙与个体血清白蛋白浓度之间存在统计学意义的相关性。
