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10-羟基-δ2-癸烯酸，一种存在于蜂王浆中的抗生素。

10-Hydroxy-delta 2-decenoic acid, an antibiotic found in royal jelly.

作者信息

BLUM M S, NOVAK A F, TABER S

出版信息

Science. 1959 Aug 21;130(3373):452-3. doi: 10.1126/science.130.3373.452.

DOI:10.1126/science.130.3373.452
PMID:13675771
Abstract

10-Hydroxy-Delta(2)-decenoic acid, the major component of the lipide fraction of royal jelly, exhibits antibiotic activity against many bacteria and fungi. This fatty acid is less than one-fourth as active as penicillin against Micrococcus pyogenes and less than one-fifth as active as chlortetracycline against Escherichia coli. It also slows the growth rate of Neurospora sitophila and some unidentified molds. The salt of this compound is considerably less active than the free acid.

摘要

10-羟基-Δ(2)-癸烯酸是蜂王浆脂质部分的主要成分，对许多细菌和真菌具有抗菌活性。这种脂肪酸对化脓性微球菌的活性不到青霉素的四分之一，对大肠杆菌的活性不到金霉素的五分之一。它还会减缓嗜热栖热放线菌和一些未鉴定霉菌的生长速度。该化合物的盐类活性比游离酸低得多。

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1
10-Hydroxy-delta 2-decenoic acid, an antibiotic found in royal jelly.10-羟基-δ2-癸烯酸，一种存在于蜂王浆中的抗生素。
Science. 1959 Aug 21;130(3373):452-3. doi: 10.1126/science.130.3373.452.
2
Identification of 10-hydroxy-delta 2-decenoic acid in royal jelly.蜂王浆中10-羟基-δ2-癸烯酸的鉴定。
Nature. 1959 Apr 4;183(4666):996-7. doi: 10.1038/183996a0.
3
Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography.柱液相色谱法测定纯蜂王浆及蜂王浆制品中反式-10-羟基-2-癸烯酸的含量
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Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly.液相色谱法测定含蜂王浆商业产品中反式-10-羟基-2-癸烯酸的含量
J AOAC Int. 1995 Jul-Aug;78(4):1019-23.
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Optimized determination method for trans-10-hydroxy-2-decenoic acid content in royal jelly by high-performance liquid chromatography with an internal standard.高效液相色谱内标法测定蜂王浆中反式-10-羟基-2-癸烯酸含量的优化方法
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Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera).从蜜蜂（意大利蜜蜂）蜂王浆中分离并鉴定10-羟基-2-癸烯酸的一些羟基脂肪酸酯和磷酸酯。
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Studies on the in vitro antitumor activity of fatty acids. IV. The esters of acids closely related to 10-hydroxy-2-decenoic acids from royal jelly against transplantable mouse leukemia.脂肪酸的体外抗肿瘤活性研究。IV. 与蜂王浆中10-羟基-2-癸烯酸密切相关的酸的酯对可移植性小鼠白血病的作用
Can J Biochem Physiol. 1961 Nov;39:1765-70. doi: 10.1139/o61-195.
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Determination of 10-Hydroxy-2-Decenoic Acid of Royal Jelly Using Near-Infrared Spectroscopy Combined with Chemometrics.采用近红外光谱结合化学计量学测定蜂王浆中的 10-羟基-2-癸烯酸。
J Food Sci. 2019 Sep;84(9):2458-2466. doi: 10.1111/1750-3841.14748. Epub 2019 Sep 4.
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10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells.蜂王浆中的 10-羟基-2-癸烯酸具有杀菌和抗炎活性，可作用于人类结肠癌细胞。
BMC Complement Altern Med. 2018 Jul 3;18(1):202. doi: 10.1186/s12906-018-2267-9.
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[Effects of royal jelly and 10-hydroxy decenoic acid on the sebaceous glands of hamster ear].蜂王浆及10-羟基癸烯酸对金黄地鼠耳部皮脂腺的影响
Nihon Hifuka Gakkai Zasshi. 1988 Apr;98(4):469-75.

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