糖蛋白的寡糖：影响寡糖结构的生物工艺因素及其对糖蛋白性质的影响。
The oligosaccharides of glycoproteins: bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties.
作者信息
Goochee C F, Gramer M J, Andersen D C, Bahr J B, Rasmussen J R
机构信息
Department of Chemical Engineering, Stanford University, CA 94305-5025.
出版信息
Biotechnology (N Y). 1991 Dec;9(12):1347-55. doi: 10.1038/nbt1291-1347.
PMID:1367768
Abstract
In this review, we organize the recent data concerning the effects of bioprocess factors on the oligosaccharide structure of human therapeutic glycoproteins, with particular emphasis on the influence of the host cell. We also discuss the effect of oligosaccharide structure on glycoprotein properties, including antigenicity, immunogenicity and plasma clearance rate.
摘要
在本综述中，我们整理了有关生物工艺因素对人治疗性糖蛋白寡糖结构影响的最新数据，特别强调宿主细胞的影响。我们还讨论了寡糖结构对糖蛋白性质的影响，包括抗原性、免疫原性和血浆清除率。
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