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[世界卫生组织新分类中的恶性淋巴瘤和白血病概念]

[Malignant lymphoma and leukemia concepts in new WHO classification].

作者信息

Kikuchi Masahiro

机构信息

Department of Pathology, School of Medicine, Fukuoka University, Fukuoka 814-0180.

出版信息

Rinsho Byori. 2003 Aug;51(8):820-4.

Abstract

The new WHO classification is based on the principles of REAL classification of lymphoma and expands to myeloid, mast cell and histiocytic/dendritic neoplasms. The distinct diseases are defined according to a combination of morphology, immunophenotype, genetic features, and clinical syndromes, and the cell origin is postulated. Lymphatic leukemia is included in lymphoma. The lymphoid malignancies are grouped into B cell lymphoma, T/NK cell lymphoma and Hodgkin lymphoma, and the myeloid neoplasm are grouped into 4 categories; chronic myeloproliferative diseases(chronic myelogeneous leukemia, polycythemia vera, chronic idiopathic myelofibrosis, essential thrombocythemia etc.), myelodysplastic/myeloproliferative diseases (chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia etc.), myelodysplastic diseases(perfactory anemia, refractory anemia with ringed sideroblasts etc.) and acute myeloid leukemia.

摘要

世界卫生组织(WHO)的新分类基于淋巴瘤REAL分类原则,并扩展至髓系、肥大细胞及组织细胞/树突状细胞肿瘤。根据形态学、免疫表型、遗传学特征及临床综合征的综合情况定义不同疾病,并推测细胞起源。淋巴性白血病包含在淋巴瘤中。淋巴系统恶性肿瘤分为B细胞淋巴瘤、T/NK细胞淋巴瘤和霍奇金淋巴瘤,髓系肿瘤分为4类:慢性髓细胞增殖性疾病(慢性粒细胞白血病、真性红细胞增多症、慢性特发性骨髓纤维化、原发性血小板增多症等)、骨髓增生异常/骨髓增殖性疾病(慢性粒单核细胞白血病、青少年粒单核细胞白血病等)、骨髓增生异常疾病(难治性贫血、伴有环形铁粒幼细胞的难治性贫血等)和急性髓系白血病。

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