Jaffe E S, Harris N L, Diebold J, Muller-Hermelink H K
Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.
Am J Clin Pathol. 1999 Jan;111(1 Suppl 1):S8-12.
The World Health Organization (WHO) classification has been developed under the joint auspices of the European Association for Hematopathology (EAHP) and the Society for Hematopathology (SH). First organized in 1995, the Steering Committee appointed 10 committees for T-cell and B-cell lymphomas and leukemias and myeloid and histiocytic tumors to develop a relevant list of diseases and establish definitions of each disease according to established criteria. The WHO classification uses the principles of the Revised European American Classification of Lymphoid Neoplasms (REAL), which defines each disease according to its morphologic features, immunophenotype, genetic features, postulated normal counterpart, and clinical features. The proposed classification was presented at the United States-Canadian Academy of Pathology meeting in 1997. The Steering Committee also appointed a Clinical Advisory Committee to ensure that the classification meets clinical needs and to resolve questions of clinical significance. The proposed WHO classification for lymphomas is similar to the REAL classification for lymphomas, with minor modifications and reassessment of provisional categories based on new data since 1994.
世界卫生组织（WHO）分类是在欧洲血液病理学协会（EAHP）和血液病理学学会（SH）的联合主持下制定的。指导委员会于1995年首次组建，任命了10个委员会负责T细胞和B细胞淋巴瘤及白血病以及髓系和组织细胞肿瘤，以制定相关疾病清单，并根据既定标准确定每种疾病的定义。WHO分类采用了修订的欧美淋巴样肿瘤分类（REAL）的原则，该原则根据疾病的形态学特征、免疫表型、遗传学特征、假定的正常对应物和临床特征来定义每种疾病。提议的分类于1997年在美国 - 加拿大病理学会会议上公布。指导委员会还任命了一个临床咨询委员会，以确保分类满足临床需求并解决临床意义方面的问题。提议的WHO淋巴瘤分类与淋巴瘤的REAL分类相似，自1994年以来基于新数据对临时类别进行了细微修改和重新评估。
