Leonard Stephen S, Xia Chang, Jiang Bin-Hua, Stinefelt Beth, Klandorf Hillar, Harris Gabriel K, Shi Xianglin
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Biochem Biophys Res Commun. 2003 Oct 3;309(4):1017-26. doi: 10.1016/j.bbrc.2003.08.105.
Scavenging or quenching of the reactive oxygen species (ROS) involved in oxidative stress has been the subject of many recent studies. Resveratrol, found in various natural food products, has been linked to decreased coronary artery disease and preventing cancer development. The present study measured the effect of resveratrol on several different systems involving the hydroxyl, superoxide, metal/enzymatic-induced, and cellular generated radicals. The rate constant for reaction of resveratrol with the hydroxyl radical was determined, and resveratrol was found to be an effective scavenger of hydroxyl, superoxide, and metal-induced radicals as well as showing antioxidant abilities in cells producing ROS. Resveratrol exhibits a protective effect against lipid peroxidation in cell membranes and DNA damage caused by ROS. Resveratrol was also found to have a significant inhibitory effect on the NF-kappaB signaling pathway after cellular exposure to metal-induced radicals. It was concluded that resveratrol in foods plays an important antioxidant role.
清除或淬灭参与氧化应激的活性氧（ROS）一直是近期许多研究的主题。在各种天然食品中发现的白藜芦醇，与降低冠状动脉疾病风险及预防癌症发展有关。本研究测定了白藜芦醇对涉及羟基、超氧化物、金属/酶诱导以及细胞产生的自由基的几种不同体系的影响。测定了白藜芦醇与羟基自由基反应的速率常数，发现白藜芦醇是羟基、超氧化物和金属诱导自由基的有效清除剂，并且在产生ROS的细胞中表现出抗氧化能力。白藜芦醇对细胞膜中的脂质过氧化和ROS引起的DNA损伤具有保护作用。还发现细胞暴露于金属诱导的自由基后，白藜芦醇对NF-κB信号通路具有显著的抑制作用。得出的结论是，食物中的白藜芦醇起着重要的抗氧化作用。
