泽克氏卫矛茎皮的生物活性成分。

Bioactive constituents of the stem bark of Beilschmiedia zenkeri.

机构信息

Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, P.O. Box 47, Yaoundé, Cameroon.

出版信息

J Nat Prod. 2009 Dec;72(12):2130-4. doi: 10.1021/np900341f.

PMID:19904919

Abstract

Phytochemical investigation of the stem bark of Beilschmiedia zenkeri led to the isolation of four new methoxylated flavonoid derivatives, (2S,4R)-5,6,7-trimethoxyflavan-4-ol (1), (2S,4R)-4,5,6,7-tetramethoxyflavan (2), beilschmieflavonoid A (3), and beilschmieflavonoid B (4), together with seven known compounds. The structures of 1-4 were established by spectroscopic methods, and their relative configurations confirmed by X-ray crystallographic and CD analysis. The isolated compounds were evaluated in vitro for their antibacterial activity against three strains of bacteria, Pseudomonas agarici, Bacillus subtilis, and Streptococcus minor, and for their antiplasmodial activity against Plasmodium falciparum, chloroquine-resistant strain W2.

摘要

对锡叶藤茎皮的植物化学研究导致了四个新的甲氧基黄酮类衍生物的分离，（2S,4R）-5,6,7-三甲氧基黄烷-4-醇（1），（2S,4R）-4,5,6,7-四甲氧基黄烷（2），锡叶藤黄酮 A（3）和锡叶藤黄酮 B（4），以及七个已知的化合物。通过光谱方法确定了 1-4 的结构，并通过 X 射线晶体学和 CD 分析确定了它们的相对构型。对分离得到的化合物进行了体外抗菌活性评价，针对三种细菌，粘质沙雷氏菌、枯草芽孢杆菌和微小链球菌，以及抗疟原虫活性评价，针对氯喹抗性株 W2。