(3,4-二芳基-3H-噻唑-2-亚基)肼衍生物的合成及其抗分枝杆菌活性
Synthesis and antimycobacterial activity of (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives.
作者信息
Mamolo Maria Grazia, Falagiani Valeria, Zampieri Daniele, Vio Luciano, Banfi Elena, Scialino Giuditta
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy.
出版信息
Farmaco. 2003 Sep;58(9):631-7. doi: 10.1016/S0014-827X(03)00103-4.
Abstract
[5-(pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed an interesting activity against a strain of Mycobacterium tuberculosis H(37)Rv and three clinical isolates of M. tuberculosis.
摘要
合成了[5-(吡啶-2-基)-1,3,4-噻二唑-2-基硫代]乙酸(3,4-二芳基-3H-噻唑-2-亚基)酰肼衍生物，并对其体外抗分枝杆菌活性进行了测试。一些化合物对结核分枝杆菌H(37)Rv菌株和三株结核分枝杆菌临床分离株表现出有趣的活性。
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