Nishimoto Norihiro
Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, Japan.
Autoimmunity. 2005 Aug;38(5):359-67. doi: 10.1080/08916930500124106.
Understanding of biological activities of cytokines and exquisite mechanism to regulate their functions has facilitated the therapeutic concept to restore the disequilibrium between pro-inflammatory cytokines and anti-inflammatory cytokines or cytokine inhibitors in some autoimmune inflammatory diseases such as rheumatoid arthritis (RA) and Crohn's disease. The application of molecular biology techniques to design monoclonal antibodies, soluble receptors, or receptor antagonists as therapeutic biologic agents made it possible to regulate the cytokine signals for the treatment of the diseases refractory to conventional therapies. Japanese researchers have contributed considerably to the establishment of cytokine signal regulation in autoimmune diseases. In this article, Japanese studies of cytokine signal regulation, particularly for Interleukin-6 (IL-6) in autoimmune diseases are reviewed.
对细胞因子生物学活性及其调节功能的精妙机制的理解，推动了一种治疗理念的发展，即在类风湿关节炎（RA）和克罗恩病等自身免疫性炎症疾病中，恢复促炎细胞因子与抗炎细胞因子或细胞因子抑制剂之间的失衡状态。应用分子生物学技术设计单克隆抗体、可溶性受体或受体拮抗剂作为治疗性生物制剂，使得调节细胞因子信号以治疗传统疗法难治的疾病成为可能。日本研究人员为自身免疫性疾病中细胞因子信号调节的建立做出了巨大贡献。本文将对日本在自身免疫性疾病中细胞因子信号调节的研究进行综述，尤其关注白细胞介素-6（IL-6）的相关研究。
