Min Jiho, Lee Chang Woo, Gu Man Bock
National Research Laboratory of Environmental Biotechnology, Kwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, 500-712 Gwangju, Republic of Korea.
Radiat Environ Biophys. 2003 Oct;42(3):189-92. doi: 10.1007/s00411-003-0205-8. Epub 2003 Sep 11.
In order to investigate the relationship between radiation dose-rate and bacterial DNA damage as well as general cellular toxicity, two recombinant Escherichia coli strains, DPD2794 and GC2 were used. Following gamma-ray irradiation, these bioluminescent bacteria showed quantitative stress responses in terms of DNA damage and general toxicity depending on the dose rates of energy deposition, i.e. dose-rate of radiation. In addition, an inverse relationship was found, at lower dose rates between 0.5 and 1 Gy/h and a parabolic relationship at dose rates between 0.5 and 2.6 Gy/h.
为了研究辐射剂量率与细菌DNA损伤以及一般细胞毒性之间的关系，使用了两种重组大肠杆菌菌株，DPD2794和GC2。在γ射线照射后，这些发光细菌根据能量沉积的剂量率，即辐射剂量率，在DNA损伤和一般毒性方面表现出定量的应激反应。此外，还发现了一种反比关系，在0.5至1 Gy/h的较低剂量率之间，以及在0.5至2.6 Gy/h的剂量率之间呈抛物线关系。
