Burdmann Emmanuel A, Andoh Takeshi F, Yu Luis, Bennett William M
Division of Nephrology, São José do Rio Preto Medical School, São José do Rio Preto, Brazil.
Semin Nephrol. 2003 Sep;23(5):465-76. doi: 10.1016/s0270-9295(03)00090-1.
After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.
在使用环孢素20多年后，其肾毒性仍然是一个重大的临床问题。环孢素诱导的肾损伤已在实体器官移植受者和接受自身免疫性疾病治疗的患者中有所描述。它以两种不同且特征明确的形式表现出来，即急性肾毒性和慢性肾毒性。本文综述了当前文献，分析了有关急性和慢性环孢素诱导肾毒性的发病机制和机制的现有数据。将提供关于慢性环孢素肾毒性可能机制的一个可行假说。
