Rukkumani R, Sri Balasubashini M, Menon Venugopal P
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Phytother Res. 2003 Sep;17(8):925-9. doi: 10.1002/ptr.1254.
Alcohol is a neurotoxin associated with significant morbidity and mortality. Ethanol is found to induce a dose dependent increase in lipid peroxidation (LPO). The elevation in lipid peroxidative products and the loss of antioxidant defense potential are enhanced when alcohol is taken along with polyunsaturated fatty acid (PUFA) or heated PUFA. The present study was undertaken to evaluate the effects of curcumin and photo-irradiated curcumin on alcohol and PUFA induced LPO and lipid pro fi les in plasma. The levels of vitamin C and E were decreased significantly in alcohol + raw as well as heated PUFA groups. The treatment with curcumin and photo-irradiated curcumin (IC) increased their levels significantly. The increase was more significant in the IC group than the curcumin group. The levels of cholesterol, phospholipids (PL), triglycerides (TG), free fatty acids (FFA), thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP) were increased significantly in alcohol + raw as well as heated PUFA groups and the treatment with curcumin and IC, brought back the levels. But the IC reduced the levels more significantly than curcumin. Thus, our results indicate that IC is a more potent antioxidant than curcumin.
酒精是一种与严重发病率和死亡率相关的神经毒素。已发现乙醇会导致脂质过氧化（LPO）呈剂量依赖性增加。当酒精与多不饱和脂肪酸（PUFA）或加热的PUFA一起摄入时，脂质过氧化产物的升高和抗氧化防御潜能的丧失会加剧。本研究旨在评估姜黄素和光照射姜黄素对酒精和PUFA诱导的血浆LPO及脂质谱的影响。在酒精+生PUFA组以及加热PUFA组中，维生素C和E的水平显著降低。用姜黄素和光照射姜黄素（IC）治疗可显著提高它们的水平。IC组的升高比姜黄素组更显著。在酒精+生PUFA组以及加热PUFA组中，胆固醇、磷脂（PL）、甘油三酯（TG）、游离脂肪酸（FFA）、硫代巴比妥酸反应性物质（TBARS）和氢过氧化物（HP）的水平显著升高，而用姜黄素和IC治疗可使这些水平恢复。但IC比姜黄素更显著地降低了这些水平。因此，我们的结果表明，IC是比姜黄素更有效的抗氧化剂。
