来自芜菁变种羽衣甘蓝种子的抑制性酚酰胺对RAW 264.7细胞中脂多糖诱导的一氧化氮生成的影响
Inhibitory phenolic amides on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells from Beta vulgaris var. cicla seeds.
作者信息
Kim Youngleem, Han Mi Seon, Lee Ji Suk, Kim Jinwoong, Kim Young Choong
机构信息
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea.
出版信息
Phytother Res. 2003 Sep;17(8):983-5. doi: 10.1002/ptr.1232.
Four phenolic compounds were isolated from Beta vulgaris L. var. cicla L. (Chenopodiaceae). These isolated compounds were identified as N-cis-feruloyl 3-O-methyldopamine (1), N-cis-feruloyl tyramine (2), N-trans-feruloyl 3-O-methyldopamine (3), N-trans-feruloyl tyramine (4), respectively, by spectroscopic analysis. The phenolic amides 1-4 exhibited modest inhibitory activity on LPS-activated nitric oxide production dose-dependently in RAW 264.7 cells.
从藜科甜菜属叶用甜菜中分离出四种酚类化合物。通过光谱分析，这些分离出的化合物分别被鉴定为N-顺式阿魏酰基-3-O-甲基多巴胺（1）、N-顺式阿魏酰基酪胺（2）、N-反式阿魏酰基-3-O-甲基多巴胺（3）、N-反式阿魏酰基酪胺（4）。酚酰胺1-4在RAW 264.7细胞中对脂多糖激活的一氧化氮生成表现出适度的剂量依赖性抑制活性。
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