阿托品、丙胺太林和甲哌佐酯对大鼠迷走神经刺激的胃动力及组胺刺激的胃酸分泌的影响。
The effect of atropine, propantheline and poldine on the vagally stimulated gastric motility and the histamine-stimulated acid gastric secretion in the rat.
作者信息
AARSEN P N, van NOORDWIJK J
出版信息
Br J Pharmacol Chemother. 1961 Aug;17(1):41-50. doi: 10.1111/j.1476-5381.1961.tb01102.x.
Histamine-induced acid gastric secretion in the anaesthetized rat was not diminished by poldine in a dose which reduced vagally stimulated gastric contractions by approximately 75%. A dose of atropine, twice as large as the dose which reduced gastric contractions by 75%, had no apparent effect on the histamine-stimulated acid gastric secretion up to 2 hr after the injection. Only when more than 40 times as much atropine was injected did a slight inhibition of the acid secretion occur in 80 to 120 min. Propantheline, in a dose which inhibited gastric contractions by approximately 75%, slightly diminished acid secretion in 40 to 80 min. This effect was not increased by a further dose of propantheline. It was concluded that, in so far as any inhibition of acid gastric secretion had occurred, this could not be interpreted as an anti-muscarine or a direct toxic effect, but rather as an indirect effect possibly due to interference with the blood flow through the stomach wall.
在麻醉大鼠中，波定（poldine）剂量能使迷走神经刺激引起的胃收缩减少约75%，但该剂量对组胺诱导的胃酸分泌并无影响。阿托品剂量为使胃收缩减少75%剂量的两倍，在注射后长达2小时内，对组胺刺激的胃酸分泌无明显作用。仅当注射剂量超过该剂量40倍以上时，在80至120分钟时才会出现轻微的胃酸分泌抑制。丙胺太林（Propantheline）剂量能使胃收缩抑制约75%，在40至80分钟时能使胃酸分泌略有减少。进一步增加丙胺太林剂量，该作用并未增强。由此得出结论，就胃酸分泌受到的任何抑制而言，这不能被解释为抗毒蕈碱作用或直接毒性作用，而更可能是由于干扰胃壁血流导致的间接作用。
Zotero 插件