AARSEN P N, van NOORDWIJK J
Br J Pharmacol Chemother. 1961 Aug;17(1):41-50. doi: 10.1111/j.1476-5381.1961.tb01102.x.
Histamine-induced acid gastric secretion in the anaesthetized rat was not diminished by poldine in a dose which reduced vagally stimulated gastric contractions by approximately 75%. A dose of atropine, twice as large as the dose which reduced gastric contractions by 75%, had no apparent effect on the histamine-stimulated acid gastric secretion up to 2 hr after the injection. Only when more than 40 times as much atropine was injected did a slight inhibition of the acid secretion occur in 80 to 120 min. Propantheline, in a dose which inhibited gastric contractions by approximately 75%, slightly diminished acid secretion in 40 to 80 min. This effect was not increased by a further dose of propantheline. It was concluded that, in so far as any inhibition of acid gastric secretion had occurred, this could not be interpreted as an anti-muscarine or a direct toxic effect, but rather as an indirect effect possibly due to interference with the blood flow through the stomach wall.
在麻醉大鼠中，波定（poldine）剂量能使迷走神经刺激引起的胃收缩减少约75%，但该剂量对组胺诱导的胃酸分泌并无影响。阿托品剂量为使胃收缩减少75%剂量的两倍，在注射后长达2小时内，对组胺刺激的胃酸分泌无明显作用。仅当注射剂量超过该剂量40倍以上时，在80至120分钟时才会出现轻微的胃酸分泌抑制。丙胺太林（Propantheline）剂量能使胃收缩抑制约75%，在40至80分钟时能使胃酸分泌略有减少。进一步增加丙胺太林剂量，该作用并未增强。由此得出结论，就胃酸分泌受到的任何抑制而言，这不能被解释为抗毒蕈碱作用或直接毒性作用，而更可能是由于干扰胃壁血流导致的间接作用。
