Bieberdorf F A, Walsh J H, Fordtran J S
Gastroenterology. 1975 Jan;68(1):50-7.
An oral optimum therapeutic dose of poldine was established in 5 normal subjects. Acid secretion in response to a protein meal was measured for 3 hr by continuous intragastric titration with sodium bicarbonate. Poldine 30 min before the meal reduced food-stimulated acid secretion from zero to 60% in the 5 subjects (average inhibition 32%). Poldine inhibited histamine-stimulated acid secretion to approximately the same extent. In separate experiments, gastric acidity after the meal was allowed to seek its natural level (i.e., there was notitration with bicarbonate). Poldine reduced average hydrogen concentration of the gastric contents by 85 to 50% from 1.5 to 3 hr after the meal. Since poldine did not alter the volume or the buffer content of the stomach, poldine inhibition of gastric acidity is due entirely to reduction of acid secretion and not to delayed emptying of food buffer. Poldine had no consistent effect on serum gastrin concentration after the meal when pH was maintained at a constant level by titration with bicarbonate; therefore, poldine inhibition of acid secretion is not mediated by a reduction of serum gastrin concentration.
在5名正常受试者中确定了口服波定宁的最佳治疗剂量。通过用碳酸氢钠连续胃内滴定法测量对蛋白质餐的胃酸分泌3小时。进餐前30分钟服用波定宁可使5名受试者中食物刺激的胃酸分泌从零减少到60%（平均抑制率32%）。波定宁可在大致相同程度上抑制组胺刺激的胃酸分泌。在单独的实验中，让进餐后的胃酸度达到其自然水平（即不进行碳酸氢钠滴定）。波定宁使进餐后1.5至3小时胃内容物的平均氢离子浓度从1.5降至3，降低了85%至50%。由于波定宁不改变胃的容积或缓冲物质含量，波定宁对胃酸度的抑制完全是由于胃酸分泌减少，而不是食物缓冲物质排空延迟。当通过碳酸氢钠滴定使pH维持在恒定水平时，波定宁对进餐后血清胃泌素浓度没有一致的影响；因此，波定宁对胃酸分泌的抑制不是由血清胃泌素浓度降低介导的。
