Noble P T
Fluor Daniel GmbH, Wiesbaden, Germany.
Biotechnol Prog. 1992 Jul-Aug;8(4):275-84. doi: 10.1021/bp00016a003.
SIP (sterilization-in-place) of equipment using saturated steam is limited by transport processes that restrict the distribution of sterilizing steam. The following are two crucial operations: the removal of air prior to sterilization, and the removal of condensate during the sterilization. Using simple model systems of pipes and tanks, characteristic operating parameters were examined and steady-state models were analyzed. The results were used to evaluate design aspects of SIP, including heat insulation, spacing of steam traps, sloping of lines, steam velocities and consumption, placement of temperature sensors, and scale factors in piping. A more reliable SIP design is achievable by insulating equipment, spacing steam traps to limit condensate buildup, providing an effective air removal operation, and providing reliable, high-quality steam.
使用饱和蒸汽对设备进行在位灭菌（SIP）受到限制灭菌蒸汽分布的传输过程的制约。以下是两个关键操作：灭菌前的空气去除，以及灭菌过程中的冷凝水去除。使用管道和罐体的简单模型系统，研究了特征运行参数并分析了稳态模型。结果用于评估SIP的设计方面，包括隔热、疏水阀间距、管道坡度、蒸汽流速和消耗量、温度传感器的放置以及管道中的比例因子。通过对设备进行隔热、合理设置疏水阀间距以限制冷凝水积聚、提供有效的空气去除操作以及提供可靠的高质量蒸汽，可以实现更可靠的SIP设计。
