Haque Z U, Mozaffar Z
Department of Food Science and Technology, Mississippi State University, Mississippi 39762.
Biosci Biotechnol Biochem. 1992 Aug;56(8):1351-4. doi: 10.1271/bbb.56.1351.
The effect of nil (control), 1% (CH-1) and 5% (CH-5) dietary cholesterol on the myelination of mouse brain, and its deposition in the heart and liver were investigated during infancy. Swiss Webstar female mice were given formulated diets from early gestation, and their pups were weaned on the same diet as that of the individual mothers up to 60 days after birth. The test diets increased the liver weight and cholesterol content compared to the control even in suckling pups (20 days), but did not significantly influence the heart weight until 60 days. The cholesterol content of the heart was not increased by the CH-1 diet throughout the feeding period, but it did increase the mole ratio of major myelin lipids and hastened its maturation. Myelin cholesterol was 10% higher in 20-day-old suckling pups in the CH-5 group compared to the control. Data indicate that dietary cholesterol altered the brain myelination rate of weaning mice, and that the mother's dietary cholesterol influenced myelination of the suckling pups.
在小鼠幼年时期，研究了零（对照）、1%（CH - 1）和5%（CH - 5）膳食胆固醇对小鼠脑髓鞘形成的影响，以及其在心脏和肝脏中的沉积情况。从妊娠早期开始，给瑞士Webstar雌性小鼠喂食配方饲料，其幼崽在出生后60天内一直与各自母亲食用相同的饲料。与对照组相比，即使在哺乳期幼崽（20日龄）中，试验饲料也增加了肝脏重量和胆固醇含量，但直到60日龄时对心脏重量没有显著影响。在整个喂养期间，CH - 1饲料并未增加心脏中的胆固醇含量，但它确实增加了主要髓鞘脂质的摩尔比并加速了其成熟。与对照组相比，CH - 5组20日龄哺乳期幼崽的髓鞘胆固醇高出10%。数据表明，膳食胆固醇改变了断奶小鼠的脑髓鞘形成速率，并且母亲的膳食胆固醇会影响哺乳期幼崽的髓鞘形成。
