Hulbron G, Aubert R, Bourgeois F, Lemonnier D
J Nutr. 1982 Jul;112(7):1296-305. doi: 10.1093/jn/112.7.1296.
The effects of exposure to cholesterol in early life on diet-induced hypercholesterolemia in adult rats were investigated. Experiment 1: dams and their offspring received either a control or a cholesterol-enriched diet during gestation and lactation; at 7 weeks of age half of the rats fed each diet were switched to the other diet for 50 weeks. Experiment 2: adult males 6 months old were fed one of the 2 experimental diets for 10 weeks, at which time half of the rats in each group were switched to the other diet for 50 weeks. Cholesterol, triglycerides and phospholipids were determined in liver, serum, heart and aorta at different ages. In both experiments, feeding a cholesterol-enriched diet induced an increase in serum and liver cholesterol and triglyceride levels, but serum phospholipid levels were not influenced by diet. The cholesterol-enriched diet induced a decrease in liver phospholipid levels. Old rats (experiment 2) fed the cholesterol-enriched diet exhibited higher heart cholesterol level than controls. In experiment 1 rats fed the cholesterol-enriched diet in early life and thereafter had lower heart triglyceride levels than the 3 other groups and lower liver triglyceride levels that rats fed control diet in early life and cholesterol diet at 7 weeks. In both experiments, cholesterolemia was not influenced by the diet fed at the beginning of the test. The results indicate that cholesterol given in early life does not protect against diet-induced hypercholesterolemia in adult rats.
研究了早年暴露于胆固醇对成年大鼠饮食诱导的高胆固醇血症的影响。实验1：在妊娠和哺乳期，母鼠及其后代分别接受对照饮食或富含胆固醇的饮食；7周龄时，每种饮食喂养的大鼠中有一半改为另一种饮食，持续50周。实验2：6月龄的成年雄性大鼠接受两种实验饮食之一，持续10周，此时每组中有一半大鼠改为另一种饮食，持续50周。在不同年龄测定肝脏、血清、心脏和主动脉中的胆固醇、甘油三酯和磷脂。在两个实验中，喂养富含胆固醇的饮食均导致血清和肝脏胆固醇及甘油三酯水平升高，但血清磷脂水平不受饮食影响。富含胆固醇的饮食导致肝脏磷脂水平降低。在实验2中，喂养富含胆固醇饮食的老年大鼠心脏胆固醇水平高于对照组。在实验1中，早年喂养富含胆固醇饮食的大鼠，其心脏甘油三酯水平低于其他3组，肝脏甘油三酯水平低于早年喂养对照饮食、7周时改为胆固醇饮食的大鼠。在两个实验中，胆固醇血症均不受试验开始时所喂饮食的影响。结果表明，早年给予胆固醇并不能预防成年大鼠饮食诱导的高胆固醇血症。
