Gatenby A A, Viitanen P V, Lorimer G H
Central Research & Development Department, E. I. Du Pont de Nemours & Co., Experimental Station, Wilmington, DE 19880-0402.
Trends Biotechnol. 1990 Dec;8(12):354-8. doi: 10.1016/0167-7799(90)90224-l.
Production of biologically active foreign proteins with correct three-dimensional structures is often difficult in bacteria. Recent advances demonstrate that, for some proteins at least, their correct folding and assembly is facilitated by a class of proteins known as molecular chaperones. An understanding of the function of molecular chaperones may assist in the synthesis in bacteria of functional foreign proteins produced by recombinant techniques.
在细菌中生产具有正确三维结构的生物活性外源蛋白质通常很困难。最近的进展表明，至少对于某些蛋白质而言，一类被称为分子伴侣的蛋白质有助于它们正确折叠和组装。了解分子伴侣的功能可能有助于利用重组技术在细菌中合成有功能的外源蛋白质。
