Stern C D
Trends Genet. 1992 May;8(5):158-63. doi: 10.1016/0168-9525(92)90217-r.
The mechanisms controlling the formation of the embryonic axis, and specifically those that give rise to the mesoderm, have received renewed attention recently. In the frog, some of these mechanisms have begun to be elucidated, and several factors have been found to cause uncommitted ectoderm cells to differentiate into mesoderm. All of the factors identified to date are related either to fibroblast growth factor (FGF) or to transforming growth factor beta (TGF-beta). Do the mechanisms that generate the embryonic axis of amphibians also operate in chick and mouse embryos? Here I address how amphibian and amniote embryos might provide complementary pieces of a puzzle.
控制胚胎轴形成的机制，尤其是那些产生中胚层的机制，近来再次受到关注。在青蛙中，其中一些机制已开始得到阐明，并且已发现几种因子可促使未分化的外胚层细胞分化为中胚层。迄今为止确定的所有因子都与成纤维细胞生长因子（FGF）或转化生长因子β（TGF-β）有关。产生两栖动物胚胎轴的机制在鸡和小鼠胚胎中也起作用吗？在此，我探讨两栖动物和羊膜动物胚胎如何可能提供一个谜题的互补部分。
