Barabas A Z, Alexander F, Lannigan R
Br J Exp Pathol. 1976 Oct;57(5):555-9.
Autologous immune-complex glomerulonephritis developed in rats injected s.c. with HgCl2 2 days before the injection of anti-tubular fraction 3 antibody. The glomerulonephritis was progressive and characterized by granular deposition of IgG and C-3, with proteinuria from the eighth week onwards. Granular densities and severe glomerular basement membrane changes were observed when the experiment was terminated after 9 months. A possible mechanism of the glomerular lesion is discussed.
在注射抗肾小管组分3抗体前两天皮下注射氯化汞的大鼠中发生了自体免疫复合物肾小球肾炎。该肾小球肾炎呈进行性,其特征为IgG和C-3的颗粒状沉积,从第八周起出现蛋白尿。在9个月后终止实验时观察到颗粒状密度和严重的肾小球基底膜变化。本文讨论了肾小球病变的一种可能机制。