Feenstra K, van den Lee R, Greben H A, Arends A, Hoedemaeker P J
Lab Invest. 1975 Feb;32(2):243-50.
In this paper, the effect of the administration of prednisone and azathioprine on an experimental immune complex glomerulonephritis is studied. During the observation period of 3 months, it appeared that prednisone had no effect either on the morphology of glomerulonephritis or on the proteinuria caused by it. Azathioprine, especially when given 4 days before or simultaneously with the induction of the experimental immune complex glomerulonephritis, showed a clear effect on the morphology of the glomerulonephritis as well as on the proteinuria. The damage to the glomerular basement membrane as a result of deposition of immune complexes was less and the proteinuria was significantly lower. The effect of azathioprine was not present when given 10 days after the induction of glomerulonephritis, at a time when the autologous phase had already developed.
本文研究了泼尼松和硫唑嘌呤对实验性免疫复合物性肾小球肾炎的影响。在3个月的观察期内，泼尼松对肾小球肾炎的形态学或其所导致的蛋白尿均无影响。硫唑嘌呤，尤其是在实验性免疫复合物性肾小球肾炎诱导前4天或同时给药时，对肾小球肾炎的形态学以及蛋白尿均显示出明显效果。免疫复合物沉积导致的肾小球基底膜损伤较轻，蛋白尿也显著降低。当在肾小球肾炎诱导10天后给药时，即自体期已经发展之时，硫唑嘌呤的效果并不存在。
