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通过静脉注射异种抗大鼠肾小管抗体诱导大鼠自体免疫复合物性肾小球肾炎。III. 长期影响。

Induction of an autologous immune complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. III. Long-term effects.

作者信息

Barabas A Z, Lannigan R

出版信息

Br J Exp Pathol. 1975 Jun;56(3):276-9.

PMID:127602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2072695/
Abstract

The long-term effects of a single intravenous injection of anti-rat kidney fraction 3 antibody were studied in rats. At the end of the experiment at one year the kidneys had deposition of immune complexes in the glomeruli staining for autologous IgG and C-3. The number and size of the deposits did not appear to increase during the experiment although proteinuria eventually developed in most test animals. Control rats injected with normal rabbit serum had no immune complexes in their kidneys.

摘要

研究了单次静脉注射抗大鼠肾组分3抗体对大鼠的长期影响。在为期一年的实验结束时，肾脏的肾小球中有免疫复合物沉积，这些复合物对自体IgG和C-3呈阳性染色。尽管大多数受试动物最终出现了蛋白尿，但在实验过程中沉积物的数量和大小似乎并未增加。注射正常兔血清的对照大鼠肾脏中没有免疫复合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b659/2072695/368aee9da923/brjexppathol00399-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b659/2072695/707168cd16ab/brjexppathol00399-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b659/2072695/368aee9da923/brjexppathol00399-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b659/2072695/707168cd16ab/brjexppathol00399-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b659/2072695/368aee9da923/brjexppathol00399-0089-b.jpg

相似文献

1
Induction of an autologous immune complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. III. Long-term effects.通过静脉注射异种抗大鼠肾小管抗体诱导大鼠自体免疫复合物性肾小球肾炎。III. 长期影响。
Br J Exp Pathol. 1975 Jun;56(3):276-9.
2
Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody IV: Effect of injection of HgCl2 prior to the antibody.通过静脉注射异种抗大鼠肾小管抗体在大鼠中诱导自体免疫复合物肾小球肾炎IV：在抗体注射前注射氯化汞的影响。
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引用本文的文献

1
Immune-complex nephritis in the rabbit produced by injections of rat renal tubular fraction 3 antigen.通过注射大鼠肾小管组分3抗原在兔中产生的免疫复合物性肾炎。
Br J Exp Pathol. 1981 Feb;62(1):94-102.
2
Progressive passive Heymann nephritis: induction of autologous antibodies to rat brush border by multiple injections of heterologous antiserum.进行性被动型海曼肾炎：通过多次注射异种抗血清诱导产生针对大鼠刷状缘的自体抗体。
Clin Exp Immunol. 1985 May;60(2):381-6.
3
Stimulation of circulating autoantibody levels in the rat with established progressive passive Heymann nephritis.

本文引用的文献

1
Passive transfer of Heymann nephritis with serum.用血清进行海曼肾炎的被动转移。
Kidney Int. 1973 Feb;3(2):66-73. doi: 10.1038/ki.1973.13.
2
Induction of an autologous immune complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. II. Early glomerular lesions.通过静脉注射异种抗大鼠肾小管抗体诱导大鼠自体免疫复合物性肾小球肾炎。II. 早期肾小球病变
Br J Exp Pathol. 1974 Jun;55(3):282-90.
3
Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. I. Production of chronic progressive immune-complex glomerulonephritis.
用已建立的进行性被动海曼肾炎刺激大鼠循环自身抗体水平。
Clin Exp Immunol. 1986 Jul;65(1):34-41.
4
Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody IV: Effect of injection of HgCl2 prior to the antibody.通过静脉注射异种抗大鼠肾小管抗体在大鼠中诱导自体免疫复合物肾小球肾炎IV：在抗体注射前注射氯化汞的影响。
Br J Exp Pathol. 1976 Oct;57(5):555-9.
通过静脉注射异种抗大鼠肾小管抗体诱导大鼠自体免疫复合物性肾小球肾炎。I. 慢性进行性免疫复合物性肾小球肾炎的产生
Br J Exp Pathol. 1974 Feb;55(1):47-55.