Altemus M, Pigott T, Kalogeras K T, Demitrack M, Dubbert B, Murphy D L, Gold P W
Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, Md 20892.
Arch Gen Psychiatry. 1992 Jan;49(1):9-20. doi: 10.1001/archpsyc.1992.01820010009002.
In light of prior data that the central administration of vasopressin in animals is associated with abnormal persistence of behaviors acquired under aversive conditioning, we studied the secretion of arginine vasopressin into the cerebrospinal fluid and plasma in patients with obsessive-compulsive disorder and controls. Patients with obsessive-compulsive disorder had significantly elevated basal levels of arginine vasopressin in the cerebrospinal fluid and significantly increased secretion of arginine vasopressin into the plasma in response to hypertonic saline administration. Moreover, seven of 12 patients with obsessive-compulsive disorder showed a loss of the normal linear relationship between plasma arginine vasopressin level and osmolality. In addition, cerebrospinal fluid corticotropin releasing hormone, which has synergistic effects with arginine vasopressin centrally and at the pituitary gland, was also significantly elevated in patients with obsessive-compulsive disorder compared with controls.
鉴于先前的数据表明，在动物中进行血管加压素的中枢给药与在厌恶条件下习得行为的异常持续有关，我们研究了强迫症患者和对照组中精氨酸血管加压素向脑脊液和血浆中的分泌情况。强迫症患者脑脊液中精氨酸血管加压素的基础水平显著升高，并且在给予高渗盐水后，精氨酸血管加压素向血浆中的分泌显著增加。此外，12名强迫症患者中有7名患者血浆精氨酸血管加压素水平与渗透压之间的正常线性关系丧失。另外，与对照组相比，强迫症患者脑脊液中的促肾上腺皮质激素释放激素也显著升高，该激素在中枢和垂体与精氨酸血管加压素具有协同作用。
