Altemus M, Pigott T, L'Heureux F, Davis C L, Rubinow D R, Murphy D L, Gold P W
Laboratory of Clinical Science, NIMH, Bethesda, MD.
Am J Psychiatry. 1993 Mar;150(3):460-4. doi: 10.1176/ajp.150.3.460.
Because the central administration of somatostatin to experimental animals produces behaviors with some similarities to the compulsions of patients with obsessive-compulsive disorder and because serotonin reuptake inhibitors have been reported to reduce brain content of somatostatin, the authors examined central somatostatin activity in patients with obsessive-compulsive disorder.
CSF for measurement of somatostatin was obtained from 15 drug-free outpatients with obsessive-compulsive disorder and 27 normal volunteers.
The mean CSF somatostatin level was significantly higher in the patients with obsessive-compulsive disorder than in the normal subjects.
Although the functional significance of this finding is unknown, these data are consistent with a role for somatostatin in the clinical symptomatology of obsessive-compulsive disorder and its response to neuropharmacological agents. The high levels of CSF somatostatin reported here in a patient subgroup whose predominant symptoms consisted of overly focused, perseverative thought processes are in contrast to the consistently low levels of CSF somatostatin seen in patients with a spectrum of disorders characterized by substantial cognitive deficits.
由于向实验动物中枢给予生长抑素会产生一些与强迫症患者的强迫行为相似的行为，并且有报道称5-羟色胺再摄取抑制剂会降低大脑中生长抑素的含量，因此作者研究了强迫症患者的中枢生长抑素活性。
从15名未服用药物的强迫症门诊患者和27名正常志愿者中获取用于测量生长抑素的脑脊液。
强迫症患者脑脊液中生长抑素的平均水平显著高于正常受试者。
尽管这一发现的功能意义尚不清楚，但这些数据与生长抑素在强迫症临床症状及其对神经药理学药物反应中的作用一致。这里报道的脑脊液生长抑素水平高的患者亚组，其主要症状包括过度专注、持续性思维过程，这与以严重认知缺陷为特征的一系列疾病患者脑脊液生长抑素水平持续较低形成对比。
