• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微管稳定剂紫杉醇对雨蛙素诱导的大鼠急性胰腺炎的保护作用。

Protective effect of a microtubule stabilizer taxol on caerulein-induced acute pancreatitis in rat.

作者信息

Ueda T, Takeyama Y, Kaneda K, Adachi M, Ohyanagi H, Saitoh Y

机构信息

Department of Surgery (1st Division), Kobe University School of Medicine, Japan.

出版信息

J Clin Invest. 1992 Jan;89(1):234-43. doi: 10.1172/JCI115567.

DOI:10.1172/JCI115567
PMID:1370296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC442841/
Abstract

The effect of taxol, which is a microtubule stabilizer, was examined in a model of acute edematous pancreatitis induced in rat by the administration of caerulein. Prophylactic administration of taxol ameliorated inhibition of pancreatic secretion, increased level of serum amylase, pancreatic edema, and histological alterations in this model. Immunofluorescence studies revealed that taxol stabilized the arrangement of microtubules by the action of promoting tubulin polymerization and prevented inhibition of pancreatic digestive enzyme secretion. In isolated rat pancreatic acini, taxol reversed the inhibition of amylase secretion induced by supramaximal concentrations of cholecystokinin octapeptide and did not affect the binding of cholecystokinin octapeptide to its receptor. The results obtained in this study suggest that microtubule disorganization is the initiating event in caerulein-induced pancreatitis and that the inhibition of pancreatic digestive enzyme secretion by interfering with intracellular vesicular transport due to microtubule disorganization causes caerulein-induced pancreatitis.

摘要

在通过注射蛙皮素诱导的大鼠急性水肿性胰腺炎模型中，研究了微管稳定剂紫杉醇的作用。在该模型中，预防性给予紫杉醇可改善胰腺分泌抑制、血清淀粉酶水平升高、胰腺水肿及组织学改变。免疫荧光研究显示，紫杉醇通过促进微管蛋白聚合作用稳定微管排列，并防止胰腺消化酶分泌受到抑制。在离体大鼠胰腺腺泡中，紫杉醇可逆转超最大浓度八肽胆囊收缩素诱导的淀粉酶分泌抑制，且不影响八肽胆囊收缩素与其受体的结合。本研究结果表明，微管紊乱是蛙皮素诱导胰腺炎的起始事件，且由于微管紊乱干扰细胞内囊泡运输导致的胰腺消化酶分泌抑制引起了蛙皮素诱导的胰腺炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/53ad7eb72e33/jcinvest00045-0254-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/d538975a2340/jcinvest00045-0251-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/f6965383cf82/jcinvest00045-0251-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/2c156b9c3c55/jcinvest00045-0252-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/c3988ad552ba/jcinvest00045-0252-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/017f982c3fcc/jcinvest00045-0252-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/512df78dbd7e/jcinvest00045-0252-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/4424eaebc4af/jcinvest00045-0253-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/d01c77b447e1/jcinvest00045-0253-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/7b8e46d54a89/jcinvest00045-0253-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/4f451312bb89/jcinvest00045-0253-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/8e587a79f309/jcinvest00045-0254-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/d020e7a630a6/jcinvest00045-0254-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/d855af7bc833/jcinvest00045-0254-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/53ad7eb72e33/jcinvest00045-0254-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/d538975a2340/jcinvest00045-0251-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/f6965383cf82/jcinvest00045-0251-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/2c156b9c3c55/jcinvest00045-0252-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/c3988ad552ba/jcinvest00045-0252-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/017f982c3fcc/jcinvest00045-0252-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/512df78dbd7e/jcinvest00045-0252-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/4424eaebc4af/jcinvest00045-0253-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/d01c77b447e1/jcinvest00045-0253-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/7b8e46d54a89/jcinvest00045-0253-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/4f451312bb89/jcinvest00045-0253-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/8e587a79f309/jcinvest00045-0254-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/d020e7a630a6/jcinvest00045-0254-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/d855af7bc833/jcinvest00045-0254-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a12/442841/53ad7eb72e33/jcinvest00045-0254-d.jpg

相似文献

1
Protective effect of a microtubule stabilizer taxol on caerulein-induced acute pancreatitis in rat.微管稳定剂紫杉醇对雨蛙素诱导的大鼠急性胰腺炎的保护作用。
J Clin Invest. 1992 Jan;89(1):234-43. doi: 10.1172/JCI115567.
2
The effect of microtubule stabilizer on rat caerulein-induced pancreatitis.微管稳定剂对大鼠雨蛙肽诱导性胰腺炎的影响。
Kobe J Med Sci. 1991 Apr;37(2):97-109.
3
Acute edematous pancreatitis impairs pancreatic secretion in rats.急性水肿性胰腺炎会损害大鼠的胰腺分泌功能。
Surgery. 1990 Mar;107(3):302-10.
4
Prevention by prostaglandins of caerulein-induced pancreatitis in rats.前列腺素对大鼠蛙皮素诱导的胰腺炎的预防作用
Lab Invest. 1989 May;60(5):677-91.
5
Effect of the microtubule-disrupting drug colchicine on rat cerulein-induced pancreatitis in comparison with the microtubule stabilizer taxol.与微管稳定剂紫杉醇相比，微管破坏药物秋水仙碱对大鼠雨蛙肽诱导的胰腺炎的影响。
Pancreas. 1995 Oct;11(3):294-302. doi: 10.1097/00006676-199510000-00013.
6
Ghrelin attenuates the development of acute pancreatitis in rat.胃饥饿素可减轻大鼠急性胰腺炎的发展。
J Physiol Pharmacol. 2003 Dec;54(4):561-73.
7
Supramaximal CCK-58 does not induce pancreatitis in the rat: role of pancreatic water secretion.超最大剂量的CCK-58不会在大鼠中诱发胰腺炎：胰腺水分分泌的作用。
Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G964-74. doi: 10.1152/ajpgi.00338.2004. Epub 2006 Dec 7.
8
Role of sensory nerves in pancreatic secretion and caerulein-induced pancreatitis.感觉神经在胰腺分泌及蛙皮素诱导的胰腺炎中的作用。
J Physiol Pharmacol. 1997 Mar;48(1):43-58.
9
Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin.瘦素和褪黑素通过中枢和外周感觉神经对胰腺完整性进行调控。
J Physiol Pharmacol. 2002 Mar;53(1):51-74.
10
Influence of ischemic preconditioning on blood coagulation, fibrinolytic activity and pancreatic repair in the course of caerulein-induced acute pancreatitis in rats.缺血预处理对大鼠蛙皮素诱导的急性胰腺炎病程中血液凝固、纤溶活性及胰腺修复的影响。
J Physiol Pharmacol. 2007 Jun;58(2):303-19.

引用本文的文献

1
Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.急性淋巴细胞白血病患者急性胰腺炎的临床和遗传危险因素
J Clin Oncol. 2016 Jun 20;34(18):2133-40. doi: 10.1200/JCO.2015.64.5812. Epub 2016 Apr 25.
2
Proteomic analysis of apoptotic and oncotic pancreatic acinar AR42J cells treated with caerulein.用 caerulein 处理的凋亡和坏死胰腺腺泡 AR42J 细胞的蛋白质组学分析。
Mol Cell Biochem. 2013 Oct;382(1-2):1-17. doi: 10.1007/s11010-013-1603-0. Epub 2013 Jul 25.
3
Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins.微管相关蛋白磷酸化对微管组装的抑制作用。
Biochemistry. 1980 May 27;19(11):2472-9. doi: 10.1021/bi00552a027.
3
Alteration of membrane fusion as a cause of acute pancreatitis in the rat.膜融合改变作为大鼠急性胰腺炎的一个病因
正常和急性胰腺炎大鼠胰腺内质网的定量细胞器蛋白质组学分析。
J Proteome Res. 2010 Feb 5;9(2):885-96. doi: 10.1021/pr900784c.
4
Blocking of monocyte chemoattractant protein-1 (MCP-1) activity attenuates the severity of acute pancreatitis in rats.阻断单核细胞趋化蛋白-1（MCP-1）的活性可减轻大鼠急性胰腺炎的严重程度。
J Gastroenterol. 2008;43(1):79-85. doi: 10.1007/s00535-007-2126-9. Epub 2008 Feb 24.
5
Possible involvement of Rab11 p24, a Ras-like small GTP-binding protein, in intracellular vesicular transport of isolated pancreatic acini.
Dig Dis Sci. 1996 Jan;41(1):133-8. doi: 10.1007/BF02208595.
Dig Dis Sci. 1982 Nov;27(11):993-1002. doi: 10.1007/BF01391745.
4
Pancreatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis.乙硫氨酸对胰腺的影响：胞吐作用的阻断以及自噬和自噬现象的出现先于细胞坏死。
Am J Physiol. 1982 Apr;242(4):G297-307. doi: 10.1152/ajpgi.1982.242.4.G297.
5
Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis.大鼠胰腺腺泡细胞的超最大剂量蛙皮素刺激与超微结构：实验性胰腺炎发展过程中的早期形态学变化
Am J Physiol. 1984 Apr;246(4 Pt 1):G457-67. doi: 10.1152/ajpgi.1984.246.4.G457.
6
Functional recovery of the exocrine pancreas after acute pancreatitis.急性胰腺炎后外分泌胰腺的功能恢复
Scand J Gastroenterol. 1983 Jan;18(1):5-8. doi: 10.3109/00365528309181549.
7
Preparation and characterization of a probe for the cholecystokinin octapeptide receptor, N alpha (125I-desaminotyrosyl)CCK-8, and its interactions with pancreatic acini.胆囊收缩素八肽受体探针Nα（125I-脱氨酪氨酰）CCK-8的制备、表征及其与胰腺腺泡的相互作用
J Biol Chem. 1981 Dec 10;256(23):12417-23.
8
Relationship of cholecystokinin receptor binding to regulation of biological functions in pancreatic acini.胆囊收缩素受体结合与胰腺腺泡生物功能调节的关系。
Am J Physiol. 1982 Mar;242(3):G250-7. doi: 10.1152/ajpgi.1982.242.3.G250.
9
Effects of ethionine on digestive enzyme synthesis and discharge by mouse pancreas.乙硫氨酸对小鼠胰腺消化酶合成与分泌的影响。
Am J Physiol. 1980 Nov;239(5):G418-26. doi: 10.1152/ajpgi.1980.239.5.G418.
10
Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores.紫杉醇可诱导活细胞中游离微管的组装，并阻断中心体和动粒的组织能力。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5608-612. doi: 10.1073/pnas.78.9.5608.