Tzaphlidou M
Laboratory of Medical Physics, Medical School, University of Ioannina, Greece.
Electron Microsc Rev. 1992;5(1):25-35. doi: 10.1016/0892-0354(92)90003-9.
Transmission electron microscopy has emerged as an ideal tool for the study and diagnosis of various disorders that involve collagen, since the information obtained by this technique is at the ultrastructural level. Structural alterations of collagen fibrils brought about by these disorders are discussed. The positive staining pattern of such fibrils is also investigated. In addition, this review describes how quantitative studies of electron-optical images from abnormal collagen fibrils can lead to information about the changes produced by collagen defects which relate to molecular or fibril architecture.
透射电子显微镜已成为研究和诊断各种涉及胶原蛋白疾病的理想工具，因为通过该技术获得的信息处于超微结构水平。本文讨论了这些疾病引起的胶原纤维结构改变。还研究了此类纤维的阳性染色模式。此外，本综述描述了如何对异常胶原纤维的电子光学图像进行定量研究，从而获得与分子或纤维结构相关的胶原缺陷所产生变化的信息。
