顺二氯二氨铂（II）-脱氧核糖核酸对正常细胞和癌细胞的作用
[Effects of the cis-dichloro-diammino-platinum(II)-deoxyribonucleic acid on normal and cancerous cells].
作者信息
Heinen N D, Desaive C, Houssier C, Gillet M C
出版信息
C R Seances Soc Biol Fil. 1976;170(4):919-21.
PMID:137067
Abstract
The effects of cis-dichloro-diammino-platinum(II) (cis-Pt) bound to DNA have been compared to those of free cis-Pt in mouse Ehrlich tumour cells, in peritoneal macrophages and in chick embryo fibroblasts cultivated in vitro. Cis-Pt has no antimitotic activity anymore when linked to DNA. This would be due to the fact that free cis-Pt is not released from cis-Pt-DNA complex inside lysosomes.
摘要
已将与DNA结合的顺二氯二氨铂（II）（顺铂）的作用与游离顺铂在小鼠艾氏瘤细胞、腹膜巨噬细胞和体外培养的鸡胚成纤维细胞中的作用进行了比较。当与DNA相连时，顺铂不再具有抗有丝分裂活性。这可能是由于游离顺铂不会从溶酶体内的顺铂-DNA复合物中释放出来。
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