Sanfilippo J S, Williams R S, Yussman M A, Cook C L, Bissonnette F
Department of Obstetrics and Gynecology, University of Louisville School of Medicine, KY 40292.
Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):155-9. doi: 10.1016/0002-9378(92)91852-2.
Substance P is a neuropeptide that has been identified in the ovary, fallopian tube, uterus, and vagina and in the hypothalamic-pituitary axis in both an animal model and human ovaries. We sought to determine if substance P is present in peritoneal fluid and, if so, whether it correlated with the cause of infertility. Its presence was determined by radioimmunoassay in the peritoneal fluid of 66 patients undergoing diagnostic laparoscopy for clinical indications related to infertility. Total volume of peritoneal fluid and cycle day were recorded; patients were evaluated in groups according to diagnosis: endometriosis (n = 24), pelvic adhesions (n = 18), and normal controls (n = 24). The level of substance P (mean +/- SEM) was 122 +/- 19 pg/ml for endometriosis and 130 +/- 19 pg/ml for pelvic adhesions. These values were not significantly different from the normal controls (130 +/- 25 pg/ml). There was no significant difference in levels between follicular and luteal phase of the menstrual cycle. We conclude that substance P is present normally in peritoneal fluid and that its levels are not affected by pelvic endometriosis or adhesions.
P物质是一种神经肽，已在动物模型和人类卵巢的卵巢、输卵管、子宫和阴道以及下丘脑-垂体轴中被鉴定出来。我们试图确定P物质是否存在于腹腔液中，如果存在，它是否与不孕原因相关。通过放射免疫分析法测定了66例因与不孕相关的临床指征而接受诊断性腹腔镜检查的患者腹腔液中P物质的存在情况。记录腹腔液总体积和月经周期日；根据诊断将患者分组评估：子宫内膜异位症（n = 24）、盆腔粘连（n = 18）和正常对照组（n = 24）。子宫内膜异位症患者的P物质水平（平均值±标准误）为122±19 pg/ml，盆腔粘连患者为130±19 pg/ml。这些值与正常对照组（130±25 pg/ml）无显著差异。月经周期的卵泡期和黄体期之间的水平无显著差异。我们得出结论，P物质正常存在于腹腔液中，其水平不受盆腔子宫内膜异位症或粘连的影响。
