Sidney S, Quesenberry C P, Sadler M C, Cattolica E V, Lydick E G, Guess H A
Kaiser Permanente Medical Care Program, Division of Research, Oakland, CA 94611.
Med Care. 1992 Feb;30(2):117-25. doi: 10.1097/00005650-199202000-00003.
The incidence of reoperation and mortality after prostatectomy was studied in 8,219 men who underwent surgical treatment for benign prostatic hypertrophy between 1976 and 1987 while they were members of the Kaiser Permanente Medical Care Program, Northern California Region. The vast majority (94.5%) received transurethral prostatectomy (TURP). The cumulative 8-year probability of a second prostatectomy was 7.6% after TURP and 2.1% after open prostatectomy. The risk of mortality associated with transurethral prostatectomy relative to open prostatectomy was 1.6 (95% confidence interval 1.2, 2.1) 8 years postsurgery. The increased risk of mortality associated with transurethral prostatectomy was most prominent during the first 5 years postsurgery (relative risk 1.8, 95% confidence interval 1.3, 2.5) and declined to 1.1 (95% confidence interval 0.8, 1.6) for deaths occurring after the first 5 years. The finding of an increased risk of mortality associated with transurethral prostatectomy is consistent with other studies and is unexplained.
对1976年至1987年期间在北加利福尼亚地区凯撒医疗保健计划中接受良性前列腺增生手术治疗的8219名男性进行了前列腺切除术后再次手术和死亡率的研究。绝大多数（94.5%）接受了经尿道前列腺切除术（TURP）。经尿道前列腺切除术后二次前列腺切除的8年累积概率为7.6%，开放性前列腺切除术后为2.1%。术后8年，经尿道前列腺切除术相对于开放性前列腺切除术的死亡风险为1.6（95%置信区间1.2, 2.1）。经尿道前列腺切除术相关的死亡风险增加在术后前5年最为显著（相对风险1.8，95%置信区间1.3, 2.5），对于术后5年后发生的死亡，该风险降至1.1（95%置信区间0.8, 1.6）。经尿道前列腺切除术相关死亡风险增加的发现与其他研究一致，且原因不明。
