Jennings G, Elia M
Medical Research Council, Dunn Nutrition Unit, Cambridge, UK.
Metabolism. 1992 Feb;41(2):141-7. doi: 10.1016/0026-0495(92)90142-w.
An assessment was made of the independent effect environmental temperature (13, 21, and 30 degrees C) and either protein deficiency or energy deficiency on the metabolic response of rats that had aseptic abscesses induced by subcutaneous injections of turpentine. Measurements of food intake, alpha 2-macroglobulin (alpha 2-M; a major acute-phase protein in the rat), albumin, and various circulating metabolites were made 48 hours after turpentine injection in animals acclimatized at 13, 21, and 30 degrees C and compared with pair-fed controls. Despite differences in basal circulating albumin concentrations between controls and protein deficient rats (P less than .001), turpentine produced a similar reduction in all groups of animals (approximately 10 g/L), independent of environmental temperature. The alpha 2-M response to turpentine was attenuated in all protein-deficient animals and also in the energy-restricted animals at 13 degrees C. The increase in circulating 3-hydroxybutyrate (BOH) and nonesterified fatty acid (NEFA) concentrations, which normally occur with reduced dietary intake, was reduced in the turpentine-injected animals to an extent that depended on prior dietary intake. It is concluded that the metabolic response, particularly the acute-phase protein response, to a standard form of "injury" is affected by protein deficiency and possibly by energy restriction under adverse environmental temperature.
评估了环境温度（13、21和30摄氏度）以及蛋白质缺乏或能量缺乏对皮下注射松节油诱导无菌性脓肿的大鼠代谢反应的独立影响。在13、21和30摄氏度环境中适应的动物，于注射松节油48小时后测量其食物摄入量、α2-巨球蛋白（α2-M；大鼠主要的急性期蛋白）、白蛋白以及各种循环代谢物，并与配对喂养的对照组进行比较。尽管对照组和蛋白质缺乏大鼠的基础循环白蛋白浓度存在差异（P<0.001），但松节油在所有动物组中产生了相似程度的降低（约10 g/L），与环境温度无关。在所有蛋白质缺乏的动物以及13摄氏度下能量受限的动物中，α2-M对松节油的反应均减弱。通常随着饮食摄入量减少而出现的循环3-羟基丁酸（BOH）和非酯化脂肪酸（NEFA）浓度升高，在注射松节油的动物中降低，降低程度取决于先前的饮食摄入量。得出的结论是，在不利的环境温度下，对标准形式“损伤”的代谢反应，尤其是急性期蛋白反应，受蛋白质缺乏以及可能的能量限制的影响。
