GUNTHER M, ASCHAFFENBURG R, MATTHEWS R H, PARISH W E, COOMBS R R
Immunology. 1960 Oct;3(4):296-306.
The coated tanned red cell technique has been used to measure the level of serum antibody in normal infants to the proteins of cow's milk. In 286 sera of infants between the ages of 7 and 97 weeks titres up to 1000 were found with the mode around 64. This distribution was quite different from that found with adult and infant cord sera. Antibodies specific for casein, α-lactalbumin and bovine plasma albumin were shown to be present but none could be shown to β-lactoglobulin. The object of the study was to get evidence that some normal infants were sufficiently sensitized to cow's milk proteins to support the hypothesis that sudden `cot death' in infants is due to an anaphylactic type of reaction consequent on inhalation of cow's milk.
包被鞣酸红细胞技术已被用于测定正常婴儿血清中针对牛奶蛋白的抗体水平。在286份7至97周龄婴儿的血清中，发现滴度高达1000，众数约为64。这种分布与成人和婴儿脐带血清中的分布有很大不同。已证明存在针对酪蛋白、α-乳白蛋白和牛血浆白蛋白的特异性抗体，但未发现针对β-乳球蛋白的抗体。该研究的目的是获取证据，证明一些正常婴儿对牛奶蛋白有足够的致敏性，以支持婴儿突然“摇篮死亡”是由于吸入牛奶后发生过敏反应这一假说。
