Crumpacker C S
Department of Infectious Diseases, Beth Israel Hospital, Boston, Massachusetts 02215.
Am J Med. 1992 Feb 14;92(2A):3S-7S. doi: 10.1016/0002-9343(92)90329-a.
Foscarnet is a pyrophosphate analogue with activity against herpesviruses, human immunodeficiency virus (HIV), and other RNA and DNA viruses. Foscarnet and its analogues achieve their antiviral effects via inhibition of viral polymerases, with such inhibition not being dependent on activation or phosphorylation of the compounds by viral or cellular proteins. Current evidence indicates that foscarnet interferes with exchange of pyrophosphate from deoxynucleoside triphosphate during viral replication by binding to a site on the herpesvirus DNA polymerase or HIV reverse transcriptase. Reviewed herein are basic findings regarding the mechanism of action and antiviral activity of foscarnet and the related compound phosphonoacetic acid (PAA), as well as findings regarding potential mechanisms of viral resistance and interactions with other antiviral agents.
膦甲酸钠是一种焦磷酸盐类似物，对疱疹病毒、人类免疫缺陷病毒（HIV）以及其他RNA和DNA病毒具有活性。膦甲酸钠及其类似物通过抑制病毒聚合酶来实现其抗病毒作用，这种抑制不依赖于病毒或细胞蛋白对化合物的激活或磷酸化。目前的证据表明，膦甲酸钠在病毒复制过程中通过与疱疹病毒DNA聚合酶或HIV逆转录酶上的一个位点结合，干扰焦磷酸从脱氧核苷三磷酸的交换。本文综述了关于膦甲酸钠和相关化合物膦酰乙酸（PAA）的作用机制和抗病毒活性的基本研究结果，以及关于病毒耐药性的潜在机制和与其他抗病毒药物相互作用的研究结果。
