膦甲酸对人疱疹病毒6型的体外抑制作用

In vitro inhibition of human herpesvirus-6 by phosphonoformate.

作者信息

Streicher H Z, Hung C L, Ablashi D V, Hellman K, Saxinger C, Fullen J, Salahuddin S Z

机构信息

National Cancer Institute, Bethesda, Maryland 20892.

出版信息

J Virol Methods. 1988 Sep;21(1-4):301-4. doi: 10.1016/0166-0934(88)90075-4.

DOI:10.1016/0166-0934(88)90075-4

PMID:2972736

Abstract

HSB-2 cell cultures productively infected with human herpesvirus-6 were treated with the antiviral drugs phosphonoformic acid (PFA), acyclovir (ACV), and gancyclovir (DHPG). ACV and DHPG showed significant toxic effects on uninfected HSB-2 cells, yet only incompletely inhibited viral expression upon infection of the cells. PFA, however, showed little direct toxicity on HSB-2 cells while viral replication was inhibited significantly.

摘要

用抗病毒药物膦甲酸（PFA）、阿昔洛韦（ACV）和更昔洛韦（DHPG）处理被人类疱疹病毒6型有效感染的HSB - 2细胞培养物。ACV和DHPG对未感染的HSB - 2细胞显示出显著的毒性作用，但在细胞感染后仅不完全抑制病毒表达。然而，PFA对HSB - 2细胞几乎没有直接毒性，同时病毒复制受到显著抑制。