Freitas V R, Fraser-Smith E B, Matthews T R
Syntex Research, Palo Alto, CA 94304.
Antiviral Res. 1989 Nov;12(4):205-12. doi: 10.1016/0166-3542(89)90030-2.
In tissue culture, efficacy against either murine CMV or HSV-2 was increased 27-fold for the acyclic nucleoside ganciclovir and 3-fold for foscarnet (trisodium phosphonoformate) when the 2 drugs were combined; whereas against human CMV, efficacy was increased 3-fold for both drugs. In mice, efficacy was increased 2-fold for ganciclovir and 4- to 5-fold for foscarnet when used in combination against either murine CMV or HSV-2. These results suggest an additive interaction between the two drugs in vivo.
在组织培养中，当将无环核苷更昔洛韦和膦甲酸钠（三钠膦酰甲酸盐）联合使用时，对鼠巨细胞病毒或单纯疱疹病毒2的效力，更昔洛韦提高了27倍，膦甲酸钠提高了3倍；而对于人巨细胞病毒，两种药物的效力均提高了3倍。在小鼠中，联合使用更昔洛韦和膦甲酸钠对抗鼠巨细胞病毒或单纯疱疹病毒2时，更昔洛韦的效力提高了2倍，膦甲酸钠提高了4至5倍。这些结果表明这两种药物在体内存在相加作用。
