DAHL L K
J Exp Med. 1960 Oct 1;112(4):635-51. doi: 10.1084/jem.112.4.635.
Among female rats and dogs which were fed excess salt for periods of about 1 and 4 years, respectively, elevations in plasma cholesterol concentrations were frequent and in some cases, quite marked. Rats on a similar regimen for only 2 and 6 months had less frequent and significantly lesser elevations of cholesterol. The lipid changes did not appear to be related primarily to increased blood pressure, kidney disease, differences in body weight or food consumption. There is no present evidence which suggests that this phenomenon is related to atherogenesis although it was speculated that this was possible.
在分别喂食过量盐分约1年和4年的雌性大鼠和狗中,血浆胆固醇浓度经常升高,在某些情况下,升高非常明显。采用类似方案仅2个月和6个月的大鼠,胆固醇升高的频率较低,且升高幅度明显较小。脂质变化似乎主要与血压升高、肾脏疾病、体重差异或食物摄入量无关。目前没有证据表明这种现象与动脉粥样硬化的发生有关,尽管有人推测这是有可能的。