DAHL L K, HEINE M, TASSINARI L
J Exp Med. 1963 Oct 1;118(4):605-17. doi: 10.1084/jem.118.4.605.
By selective inbreeding, two strains of rats were developed previously that differed markedly in their susceptibility to the development of experimental hypertension from excess salt ingestion (1, 2). The present report indicates that with animals derived from the same strains, similar differences in response were obtained in rats subjected to either combined desoxycorticosterone-NaCl (DOCA-salt) treatment or unilateral renal artery compression without extra dietary salt. Thus differences in genetic substrate appear to influence the development of experimental hypertension produced by these three techniques and possibly this may hold true for all "varieties" of experimental hypertension. If true, it might allow the development of a unifying hypothesis that could be relevant not only to experimental hypertension but perhaps to human hypertension as well. The DOCA-salt regimen was more toxic to the animals than unilateral renal artery compression. Tentatively, this was ascribed to either, or both, the younger age or the higher NaCl intake of the animals in the former.
通过选择性近亲繁殖，先前培育出了两种品系的大鼠，它们在因过量摄入盐分而患实验性高血压的易感性方面存在显著差异(1,2)。本报告表明，对于源自相同品系的动物，在接受脱氧皮质酮-氯化钠(DOCA-盐)联合治疗或单侧肾动脉结扎且无额外饮食盐分的大鼠中，也获得了类似的反应差异。因此，遗传底物的差异似乎会影响这三种技术所导致的实验性高血压的发展，并且这可能适用于所有“类型”的实验性高血压。如果这是真的，或许可以形成一个统一的假说，它不仅与实验性高血压相关，而且可能也与人类高血压相关。DOCA-盐方案对动物的毒性比单侧肾动脉结扎更大。初步认为，这要么归因于前者中动物年龄较小，要么归因于其氯化钠摄入量较高，或者两者皆有。
