Pollack A, Korte G E
Department of Ophthalmology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York 10467.
Experientia. 1992 Mar 15;48(3):219-25. doi: 10.1007/BF01930458.
Repair of the choroidal vasculature following laser photocoagulation in the rat was examined with vascular casts and correlated with observations on thin-sections. The regenerative process began at the periphery of the damaged area, starting from the surviving choriocapillaris and venules, and proceeding towards the center by means of recanalization of damaged vessels and growth of new ones. In small healed lesions the capillary bed was re-formed. It resembled the adjacent undamaged choriocapillaris morphologically but appeared to be less dense than the intact choriocapillaris when examined by scanning microscopy. In large lesions the capillary bed was re-formed at the periphery but not at the center. Also present at the edges of the large lesions were groups of new vessels which, when observed by scanning microscopy, appeared to extend in two directions; towards the subretinal space and towards the choroidal network. Another aspect of the repair process was the simultaneous occurrence of new vessel growth and capillary regression, which was observed both at the level of the choriocapillaris and at the foci of new vessels.
利用血管铸型技术研究了大鼠激光光凝后脉络膜血管系统的修复情况，并与薄切片观察结果进行了相关性分析。再生过程始于受损区域的周边，从存活的脉络膜毛细血管和小静脉开始，通过受损血管的再通和新血管的生长向中心推进。在小的愈合病变中，毛细血管床得以重新形成。其在形态上类似于相邻未受损的脉络膜毛细血管，但通过扫描显微镜检查时，其密度似乎比完整的脉络膜毛细血管低。在大的病变中，毛细血管床在周边重新形成，但中心未形成。在大病变的边缘还存在新生血管群，通过扫描显微镜观察，这些新生血管似乎向两个方向延伸，即朝向视网膜下间隙和朝向脉络膜网络。修复过程的另一个方面是新生血管生长和毛细血管消退同时发生，这在脉络膜毛细血管水平和新生血管灶处均有观察到。
