Protactin, a new antibiotic metabolite and a possible precursor of the actinomycins.
作者信息
Hanada M, Sugawara K, Nishiyama Y, Kamei H, Hatori M, Konishi M
机构信息
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1992 Jan;45(1):20-8. doi: 10.7164/antibiotics.45.20.
PMID:1372309
Abstract
Streptomyces cucumerosporus strain L703-4 (ATCC 53784) produces a new 4-methyl-3-hydroxyanthraniloylpentapeptide lactone for which we have proposed the name protactin, in addition to several actinomycin components. Protactin is rather resistant to air oxidation but it can be converted to a new actinomycin, actinomycin Zp by ferricyanide oxidation. Actinomycin Zp possesses in vitro antibacterial activity and in vivo antitumor activity against P-388 leukemia in mice.
摘要
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