和佐霉素B，一种新型抗肿瘤抗生素。

Kazusamycin B, a novel antitumor antibiotic.

作者信息

Funaishi K, Kawamura K, Sugiura Y, Nakahori N, Yoshida E, Okanishi M, Umezawa I, Funayama S, Komiyama K

出版信息

J Antibiot (Tokyo). 1987 Jun;40(6):778-85. doi: 10.7164/antibiotics.40.778.

DOI:10.7164/antibiotics.40.778

Abstract

A novel antibiotic, kazusamycin B (C32H46O7, MW 542), was isolated from the fermentation broth of Streptomyces sp. No. 81-484 and the structure was established mainly on the basis of its physico-chemical properties. Unambiguous 13C NMR spectral analysis of kazusamycin B has been also accomplished. Kazusamycin B possesses potent cytocidal activities against L1210 (IC50 0.0018 micrograms/ml) and P388 (IC100 0.0016 micrograms/ml) leukemia cells in vitro.

摘要

一种新型抗生素，和歌山霉素B（C32H46O7，分子量542），从链霉菌属No. 81 - 484的发酵液中分离得到，其结构主要根据其物理化学性质确定。和歌山霉素B的13C NMR光谱分析也已完成。和歌山霉素B在体外对L1210（IC50为0.0018微克/毫升）和P388（IC100为0.0016微克/毫升）白血病细胞具有强大的杀细胞活性。

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